ea0094ret2.1 | Section | SFEBES2023
Mulligan Lois
, Walker Tim
, Hyndman Brandy
, Reyes-Alvarez Eduardo
, Oliveira Larissa
, Richardson Douglas
, Antonescu Costin
The RET receptor tyrosine kinase is an established oncogenic driver in multiple cancers. Activating RET point mutations give rise to the cancer syndrome Multiple Endocrine Neoplasia type 2 (MEN2), characterized by medullary thyroid carcinoma and pheochromocytoma. Correlations of specific RET mutations with MEN2 disease phenotypes and severity have been well documented, however the molecular mechanisms that distinguish the functions, locations, and protein interactions of speci...